In the 2006 season, Xeneizes enjoyed a spectacular start in the Apertura, winning their first five consecutive matches under the successful leadership of manager Alfio Basile. Following Basile's departure, Ricardo La Volpe stepped in to guide the team. Key squad members included the prolific striker Martín Palermo, who scored in the Apertura final, alongside standout contributors like Pablo Ledesma, Guillermo Barros Schelotto, and Rodrigo Palacio.