The 2010-11 campaign saw Casteddu secure a safe 14th-place finish in Serie A, navigating a turbulent season defined by a mid-season managerial change from Pierpaolo Bisoli to Roberto Donadoni. The team's top goalscorer was Alessandro Matri, who netted 11 crucial goals before his January departure to Juventus. Anchored by captain Daniele Conti and featuring the emergence of the dynamic Radja Nainggolan, the season remains memorable for a spectacular 5-1 home victory over Roma and an emphatic 4-1 thrashing of champions AC Milan on the final matchday, showcasing the team's ability to surprise.