In the 2022 season, Xeneizes achieved remarkable domestic success, capturing their 35th Primera División title and winning the Copa de la Liga Profesional under the guidance of managers Sebastián Battaglia and later Hugo Ibarra. Key contributors included defensive anchor Marcos Rojo and influential midfielders Guillermo Fernández and Óscar Romero, who provided exceptional passing accuracy. Striker Darío Benedetto also rejoined the club to boost the attack. Despite a tough exit in the Copa Libertadores Round of 16 against Corinthians, the team consistently delivered when it mattered most.