The 2021-22 campaign saw Domstedelingen secure a 7th-place finish in the Eredivisie, earning a coveted spot in the European play-offs, despite the turbulence of a mid-season managerial change from René Hake to interim Rick Kruys. Leading the charge for goals were joint top scorers Bart Ramselaar and the talented new Greek striker Anastasios Douvikas, who both netted 9 times in the league; Douvikas notably scored the club's 2,500th Eredivisie goal. The season ended in heartbreak as they were narrowly defeated by Vitesse in the play-off semi-finals on away goals, but the campaign remains a memorable chapter for its attacking highlights and the team's determined, though ultimately unsuccessful, fight for Europe.